| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase C |
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| Ligand | BDBM50051941 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1453021 (CHEMBL3362103) |
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| IC50 | 154±n/a nM |
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| Citation |  Wang, HC; Jagtap, AD; Chang, PT; Liu, JR; Liu, CP; Tseng, HW; Chen, GS; Chern, JW Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor. Eur J Med Chem84:312-34 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase C |
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| Name: | Aurora kinase C |
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| Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C |
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| Type: | Enzyme |
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| Mol. Mass.: | 35602.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. |
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| Residue: | 309 |
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| Sequence: | MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
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| BDBM50051941 |
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| n/a |
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| Name | BDBM50051941 |
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| Synonyms: | CHEMBL3322565 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24N4O6 |
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| Mol. Mass. | 488.492 |
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| SMILES | COc1ccc(NC(=O)CC(=O)Nc2ccc3\C(=C\c4[nH]c(C)c(C(O)=O)c4C)C(=O)Nc3c2)cc1 |
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| Structure | 
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