Reaction Details |
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Target | Activin receptor type-1 |
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Ligand | BDBM102619 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1453218 (CHEMBL3365511) |
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IC50 | 420±n/a nM |
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Citation | Mohedas, AH; Wang, Y; Sanvitale, CE; Canning, P; Choi, S; Xing, X; Bullock, AN; Cuny, GD; Yu, PB Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem57:7900-15 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Activin receptor type-1 |
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Name: | Activin receptor type-1 |
Synonyms: | ACVR1_MOUSE | ALK2 | ActR-I | ActRIA | Acvr | Acvr1 | Acvrlk2 | Tgfb1 |
Type: | Protein |
Mol. Mass.: | 57231.35 |
Organism: | Mus musculus |
Description: | n/a |
Residue: | 509 |
Sequence: | MVDGVMILPVLMMMAFPSPSVEDEKPKVNQKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
AELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
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BDBM102619 |
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n/a |
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Name | BDBM102619 |
Synonyms: | K02288a | US10688093, Compound 382_0087_0284 | US11701353, Compound 382_0087_0284 |
Type | Small organic molecule |
Emp. Form. | C20H20N2O4 |
Mol. Mass. | 352.3838 |
SMILES | COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1cccc(O)c1 |
Structure |
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