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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM50066873 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1466123 (CHEMBL3404741) | ||
| IC50 | 2.1±n/a nM | ||
| Citation |  Ryu, JH; Kim, S; Lee, JA; Han, HY; Son, HJ; Lee, HJ; Kim, YH; Kim, JS; Park, HG Synthesis and optimization of picolinamide derivatives as a novel class of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. Bioorg Med Chem Lett25:1679-83 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM50066873 | |||
| n/a | |||
| Name | BDBM50066873 | ||
| Synonyms: | CHEMBL3401669 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H31N5O4 | ||
| Mol. Mass. | 477.5554 | ||
| SMILES | O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cccc(n1)N1CCN(CC1)c1ccc(cc1)[N+]([O-])=O)C(C3)C2 |r,wU:1.0,wD:7.8,TLB:33:32:2.3.4:6,THB:33:3:6:34.32.7,7:32:2:4.5.6,7:5:2:34.33.32,8:7:2.3.4:6,(2.78,1.14,;1.56,1.02,;1.56,2.59,;.12,3.07,;-1,2.05,;-.95,.32,;.56,-.22,;-2.19,-.22,;-3.39,-1.17,;-4.82,-.59,;-4.99,.63,;-6.03,-1.55,;-5.81,-3.07,;-7.01,-4.02,;-8.45,-3.45,;-8.67,-1.93,;-7.46,-.98,;-10.1,-1.36,;-10.32,.16,;-11.76,.73,;-12.96,-.23,;-12.74,-1.75,;-11.31,-2.32,;-14.4,.34,;-14.62,1.86,;-16.06,2.43,;-17.26,1.47,;-17.03,-.05,;-15.6,-.62,;-18.7,2.03,;-18.88,3.25,;-19.66,1.26,;-1.2,1.02,;-1.2,2.69,;.34,.44,)| | ||
| Structure | 
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