| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V1a receptor |
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| Ligand | BDBM50077226 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473358 (CHEMBL3419318) |
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| Ki | 1491±n/a nM |
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| Citation |  Ratni, H; Rogers-Evans, M; Bissantz, C; Grundschober, C; Moreau, JL; Schuler, F; Fischer, H; Alvarez Sanchez, R; Schnider, P Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem58:2275-89 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V1a receptor |
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| Name: | Vasopressin V1a receptor |
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| Synonyms: | AVPR V1a | Antidiuretic hormone receptor 1a | Avpr1a | V1AR_MOUSE | V1aR | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1a receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47202.75 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109593 |
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| Residue: | 423 |
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| Sequence: | MSFPRGSHDLPAGNSSPWWPLTTEGANSSREAAGLGEGGSPPGDVRNEELAKLEVTVLAV
IFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGP
DWLCRVVKHLQVFAMFASSYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAASWGLSFV
LSIPQYFIFSVIEFEVNNGTKAQDCWATFIPPWGTRAYVTWMTSGVFVVPVIILGTCYGF
ICYHIWRNVRGKTASRQSKGGKGSGEAAGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFV
IVSAYILCWTPFFIVQMWSVWDTNFVWTDSENPSTTITALLASLNSCCNPWIYMFFSGHL
LQDCVQSFPCCQSIAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGTWKDSPKSSKSIRFIP
VST
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| BDBM50077226 |
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| n/a |
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| Name | BDBM50077226 |
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| Synonyms: | CHEMBL3416879 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19ClN2O |
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| Mol. Mass. | 338.831 |
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| SMILES | Clc1ccc2c(c[nH]c2c1)C(=O)N1CCC(CC1)c1ccccc1 |
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| Structure | 
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