| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor IX |
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| Ligand | BDBM50125964 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1522950 (CHEMBL3630982) |
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| Ki | 22±n/a nM |
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| Citation |  Zhang, T; Andre, P; Bateman, TJ; Chen, YH; Desai, K; Ellsworth, K; Geissler, WM; Guo, L; Hruza, A; Jian, T; Meng, D; Parker, DL; Qian, X; Reichert, P; Sherer, EC; Shu, M; Smith, CJ; Sonatore, LM; Tschirret-Guth, R; Nolting, AF; Orr, R; Campeau, LC; Araki, K; Nishimura, T; Sakurada, I; Wood, HB Development of a novel class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett25:4945-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor IX |
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| Name: | Coagulation factor IX |
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| Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
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| Type: | Enzyme |
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| Mol. Mass.: | 51768.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00740 |
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| Residue: | 461 |
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| Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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| BDBM50125964 |
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| n/a |
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| Name | BDBM50125964 |
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| Synonyms: | CHEMBL3627867 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22ClF3N6O |
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| Mol. Mass. | 538.951 |
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| SMILES | Cc1cc2nc([nH]c2cc1C)[C@@H](CNC(=O)c1c(Cl)cc(cc1C(F)(F)F)-n1cnnc1)c1ccccc1 |r| |
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| Structure | 
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