Reaction Details |
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Target | Serine protease hepsin |
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Ligand | BDBM50100897 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1525565 (CHEMBL3637191) |
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Ki | 40000±n/a nM |
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Citation | Goswami, R; Wohlfahrt, G; Törmäkangas, O; Moilanen, A; Lakshminarasimhan, A; Nagaraj, J; Arumugam, KN; Mukherjee, S; Chacko, AR; Krishnamurthy, NR; Jaleel, M; Palakurthy, RK; Samiulla, DS; Ramachandra, M Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors. Bioorg Med Chem Lett25:5309-14 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine protease hepsin |
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Name: | Serine protease hepsin |
Synonyms: | HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1 |
Type: | Enzyme |
Mol. Mass.: | 45016.98 |
Organism: | Homo sapiens (Human) |
Description: | Human deglycosylated hepsin was expressed in Pichia pastoris. |
Residue: | 417 |
Sequence: | MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
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BDBM50100897 |
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n/a |
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Name | BDBM50100897 |
Synonyms: | 2-(2-Hydroxy-phenyl)-1H-benzoimidazole-5-carboxamidine | 2-(2-Hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine | 2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}BENZENOLATE | CHEMBL433501 |
Type | Small organic molecule |
Emp. Form. | C14H12N4O |
Mol. Mass. | 252.2713 |
SMILES | NC(=N)c1ccc2nc([nH]c2c1)-c1ccccc1O |
Structure |
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