| Reaction Details |
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 | Report a problem with these data |
| Target | Cholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor |
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| Ligand | BDBM50329179 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1544143 (CHEMBL3750901) |
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| IC50 | 25±n/a nM |
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| Citation |  Desai, AJ; Lam, PC; Orry, A; Abagyan, R; Christopoulos, A; Sexton, PM; Miller, LJ Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex. J Med Chem58:9562-77 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor |
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| Name: | Cholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor |
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| Synonyms: | Cholecystokinin receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1544143 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Gastrin/cholecystokinin type B receptor |
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| Synonyms: | Cckbr | Cholecystokinin A | Cholecystokinin B receptor | Cholecystokinin receptor | GASR_RAT | Gastrin/cholecystokinin type B receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48980.43 |
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| Organism: | RAT |
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| Description: | Cholecystokinin A CCKBR RAT::P30553 |
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| Residue: | 452 |
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| Sequence: | MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGL
ISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCV
QLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTW
RAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRA
RPQPLPDEDPPTPSIASLSRLSYTTISTLGPG
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| Component 2 |
| Name: | Cholecystokinin receptor type A |
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| Synonyms: | CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49676.37 |
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| Organism: | RAT |
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| Description: | Cholecystokinin central 0 RAT::P30551 |
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| Residue: | 444 |
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| Sequence: | MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQI
LLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLK
DFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAAT
WCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVM
VVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQL
SSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAE
KHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEE
DGRTIRALLSRYSYSHMSTSAPPP
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| BDBM50329179 |
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| n/a |
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| Name | BDBM50329179 |
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| Synonyms: | 2-((4S)-4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)-N-benzyl-N-isopropylacetamide | CHEMBL1269258 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H34N6O2 |
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| Mol. Mass. | 594.7049 |
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| SMILES | CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)[C@H](Cc2c[nH]c3ccccc23)C1=O |r| |
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| Structure | 
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