| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Ligand | BDBM50145450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1556012 (CHEMBL3767676) |
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| IC50 | >1000000±n/a nM |
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| Citation |  Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F Synthesis and evaluation of colletoic acid core derivatives. Eur J Med Chem110:126-32 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 44141.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purified recombinant human 11beta-HSD2. |
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| Residue: | 405 |
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| Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
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| BDBM50145450 |
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| n/a |
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| Name | BDBM50145450 |
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| Synonyms: | CHEMBL3764111 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26OS |
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| Mol. Mass. | 362.528 |
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| SMILES | CC(C)C1=CC[C@H](CSc2ccc3ccccc3c2)[C@]11CCC(=O)C=C1 |r,c:27,t:3| |
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| Structure | 
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