| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sphingosine kinase 2 |
|---|
| Ligand | BDBM50177009 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1582607 (CHEMBL3816948) |
|---|
| Ki | 9800±n/a nM |
|---|
| Citation |  Congdon, MD; Kharel, Y; Brown, AM; Lewis, SN; Bevan, DR; Lynch, KR; Santos, WL Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors. ACS Med Chem Lett7:229-34 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sphingosine kinase 2 |
|---|
| Name: | Sphingosine kinase 2 |
|---|
| Synonyms: | SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 69221.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NRA0 |
|---|
| Residue: | 654 |
|---|
| Sequence: | MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
|
|
|
|---|
| BDBM50177009 |
|---|
| n/a |
|---|
| Name | BDBM50177009 |
|---|
| Synonyms: | CHEMBL3814083 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H27ClN2O |
|---|
| Mol. Mass. | 394.937 |
|---|
| SMILES | Clc1ccc(cc1)C12CC3CC(CC(CC(=O)NCc4ccncc4)(C3)C1)C2 |TLB:8:7:25.9.10:12,10:11:26:25.9.8,THB:8:9:12:26.7.27| |
|---|
| Structure | 
|
|---|
Search and Browse
