| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine kinase 1 |
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| Ligand | BDBM50041978 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1582610 (CHEMBL3816951) |
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| Ki | 3.6±n/a nM |
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| Citation |  Congdon, MD; Kharel, Y; Brown, AM; Lewis, SN; Bevan, DR; Lynch, KR; Santos, WL Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors. ACS Med Chem Lett7:229-34 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine kinase 1 |
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| Name: | Sphingosine kinase 1 |
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| Synonyms: | SK 1 | SPHK1_MOUSE | SPK 1 | Sk1 | Sphk1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42447.37 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_107622 |
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| Residue: | 382 |
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| Sequence: | MEPVECPRGLLPRPCRVLVLLNPQGGKGKALQLFQSRVQPFLEEAEITFKLILTERKNHA
RELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPGGSGNALAASV
NHYAGYEQVTNEDLLINCTLLLCRRRLSPMNLLSLHTASGLRLYSVLSLSWGFVADVDLE
SEKYRRLGEIRFTVGTFFRLASLRIYQGQLAYLPVGTVASKRPASTLVQKGPVDTHLVPL
EEPVPSHWTVVPEQDFVLVLVLLHTHLSSELFAAPMGRCEAGVMHLFYVRAGVSRAALLR
LFLAMQKGKHMELDCPYLVHVPVVAFRLEPRSQRGVFSVDGELMVCEAVQGQVHPNYLWM
VCGSRDAPSGRDSRRGPPPEEP
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| BDBM50041978 |
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| n/a |
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| Name | BDBM50041978 |
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| Synonyms: | CHEMBL3134157 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31NO4S |
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| Mol. Mass. | 465.604 |
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| SMILES | Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1 |r| |
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| Structure | 
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