| Reaction Details |
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 | Report a problem with these data |
| Target | Smoothened homolog |
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| Ligand | BDBM50200481 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1622141 (CHEMBL3864493) |
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| IC50 | 155±n/a nM |
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| Citation |  Liu, G; Xue, D; Yang, J; Wang, J; Liu, X; Huang, W; Li, J; Long, YQ; Tan, W; Zhang, A Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists. J Med Chem59:11050-11068 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Smoothened homolog |
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| Name: | Smoothened homolog |
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| Synonyms: | SMO_MOUSE | Smo | Smoh |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87472.73 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1510377 |
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| Residue: | 793 |
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| Sequence: | MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSP
PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP
RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE
GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA
FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR
ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK
TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG
YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN
QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV
WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH
DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL
VEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLV
AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN
LMEAEILDADSDF
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| BDBM50200481 |
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| n/a |
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| Name | BDBM50200481 |
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| Synonyms: | CHEMBL3986017 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33ClN4O2 |
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| Mol. Mass. | 505.051 |
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| SMILES | [H][C@]1(CC[C@@H](C)c2ccc(CN3CCOCC3)nc12)[C@@H](C)C(=O)Nc1ccc(Cl)c(c1)-c1ccccn1 |r| |
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| Structure | 
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