Reaction Details |
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Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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Ligand | BDBM50187693 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1622711 (CHEMBL3865063) |
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IC50 | 289±n/a nM |
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Citation | Shah, P; Cheasty, A; Foxton, C; Raynham, T; Farooq, M; Gutierrez, IF; Lejeune, A; Pritchard, M; Turnbull, A; Pang, L; Owen, P; Boyd, S; Stowell, A; Jordan, A; Hamilton, NM; Hitchin, JR; Stockley, M; MacDonald, E; Quesada, MJ; Trivier, E; Skeete, J; Ovaa, H; Moolenaar, WH; Ryder, H Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorg Med Chem Lett26:5403-5410 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
Synonyms: | ATX | Autotaxin | Autotaxin (ATX) | E-NPP 2 | ENPP2 | ENPP2_HUMAN | Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP2) | Extracellular lysophospholipase D | LysoPLD | PDNP2 |
Type: | Enzyme |
Mol. Mass.: | 99007.13 |
Organism: | Homo sapiens (Human) |
Description: | Q13822 |
Residue: | 863 |
Sequence: | MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI
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BDBM50187693 |
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n/a |
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Name | BDBM50187693 |
Synonyms: | CHEMBL3186509 |
Type | Small organic molecule |
Emp. Form. | C22H21Cl2N3O5 |
Mol. Mass. | 478.325 |
SMILES | Clc1cc(Cl)cc(COC(=O)N2CCN(CCC(=O)c3ccc4[nH]c(=O)oc4c3)CC2)c1 |
Structure |
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