Ki Summary

Reaction Details

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Target

Neuronal acetylcholine receptor subunit alpha-7

Ligand

BDBM50206245

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1628642 (CHEMBL3871227)

EC50

41±n/a nM

Citation

Hill, MD; Fang, H; King, HD; Iwuagwu, CI; McDonald, IM; Cook, J; Zusi, FC; Mate, RA; Knox, RJ; Post-Munson, D; Easton, A; Miller, R; Lentz, K; Clarke, W; Benitex, Y; Lodge, N; Zaczek, R; Denton, R; Morgan, D; Bristow, L; Macor, JE; Olson, R Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] asa7 Nicotinic Receptor Agonists. ACS Med Chem Lett8:133-137 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuronal acetylcholine receptor subunit alpha-7

Name:

Neuronal acetylcholine receptor subunit alpha-7

Synonyms:

Type:

n/a

Mol. Mass.:

56448.33

Organism:

Homo sapiens (Human)

Description:

CHRNA7 (NACHRA7)

Residue:

502

Sequence:

MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA

BDBM50206245

n/a

Name

BDBM50206245

Synonyms:

CHEMBL3907100

Type

Small organic molecule

Emp. Form.

C16H20N6O

Mol. Mass.

312.3696

SMILES

Cc1ccc2c(NC3=NC[C@@]4(CN5CCC4CC5)O3)ncnn12 |r,wU:10.19,t:7,TLB:18:10:13.14:17.16,THB:9:10:13.14:17.16,(41.57,-46.49,;40.04,-46.57,;39.07,-45.37,;37.63,-45.93,;37.71,-47.46,;36.63,-48.56,;35.14,-48.16,;34.05,-49.25,;34.29,-50.77,;32.92,-51.47,;31.83,-50.38,;31.1,-51.65,;29.82,-51.07,;29.82,-49.15,;30.66,-48.07,;30.66,-49.69,;29.09,-50.37,;28.3,-51.56,;32.53,-49,;37.02,-50.04,;38.5,-50.44,;39.6,-49.36,;39.2,-47.86,)|

Structure