| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1F |
|---|
| Ligand | BDBM50130261 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2094 (CHEMBL617130) |
|---|
| Ki | <1995±n/a nM |
|---|
| Citation |  Forbes, IT; Douglas, S; Gribble, AD; Ife, RJ; Lightfoot, AP; Garner, AE; Riley, GJ; Jeffrey, P; Stevens, AJ; Stean, TO; Thomas, DR SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties. Bioorg Med Chem Lett12:3341-4 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 1F |
|---|
| Name: | 5-hydroxytryptamine receptor 1F |
|---|
| Synonyms: | 5-HT-1F | 5-HT1F | 5-hydroxytryptamine receptor 1F | 5HT1F_HUMAN | HTR1EL | HTR1F | Serotonin (5-HT) receptor | Serotonin 1f (5-HT1f) receptor | Serotonin receptor 1F |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 41724.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | 5-HT1F HTR1F HUMAN::P30939 |
|---|
| Residue: | 366 |
|---|
| Sequence: | MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANY
LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALD
RYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIV
STIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKS
VSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILG
AFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQK
LVRCRC
|
|
|
|---|
| BDBM50130261 |
|---|
| n/a |
|---|
| Name | BDBM50130261 |
|---|
| Synonyms: | 6-(2-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-ethyl}-pyrrolidine-1-sulfonyl)-1H-indole; hydrochloride | CHEMBL538029 | CHEMBL95104 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H30ClN3O3S |
|---|
| Mol. Mass. | 488.042 |
|---|
| SMILES | Clc1ccc(OC2CCN(CC[C@H]3CCCN3S(=O)(=O)c3ccc4cc[nH]c4c3)CC2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
