Reaction Details |
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Target | Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor |
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Ligand | BDBM50230777 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_34827 (CHEMBL648761) |
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IC50 | 94±n/a nM |
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Citation | Keenan, RM; Weinstock, J; Finkelstein, JA; Franz, RG; Gaitanopoulos, DE; Girard, GR; Hill, DT; Morgan, TM; Samanen, JM; Peishoff, CE Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids. J Med Chem36:1880-92 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor |
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Name: | Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor |
Synonyms: | Angiotensin II receptor | Type-1A/Type-1B/Type-2 angiotensin II receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 36477 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Type-1 angiotensin II receptor B |
Synonyms: | AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40929.44 |
Organism: | RAT |
Description: | Angiotensin II AT1B 0 RAT::P29089 |
Residue: | 359 |
Sequence: | MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
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Component 2 |
Name: | Type-2 angiotensin II receptor |
Synonyms: | AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41346.62 |
Organism: | RAT |
Description: | Angiotensin II AT2 0 0::P35351 |
Residue: | 363 |
Sequence: | MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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Component 3 |
Name: | Type-1 angiotensin II receptor A |
Synonyms: | AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40910.53 |
Organism: | RAT |
Description: | ANGIOTENSIN AT1 AGTR1 RAT::P25095 |
Residue: | 359 |
Sequence: | MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
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BDBM50230777 |
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n/a |
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Name | BDBM50230777 |
Synonyms: | CHEMBL54446 |
Type | Small organic molecule |
Emp. Form. | C23H26N4O2S |
Mol. Mass. | 422.543 |
SMILES | CCCCc1ncc(\C=C(/Cc2cccs2)C(N)=O)n1Cc1ccc(cc1)C(N)=O |
Structure |
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