Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50236286 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1658997 (CHEMBL4008609) |
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IC50 | 6.4±n/a nM |
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Citation | Ng, HL; Ma, X; Chew, EH; Chui, WK Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase. J Med Chem60:1734-1745 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50236286 |
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n/a |
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Name | BDBM50236286 |
Synonyms: | CHEMBL4079985 |
Type | Small organic molecule |
Emp. Form. | C23H28ClN5O3 |
Mol. Mass. | 457.953 |
SMILES | Cl.CC1(C)N=C(N)N=C(N)N1OCCCOc1ccc(\C=C\C(=O)c2ccccc2)cc1 |t:3,6| |
Structure |
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