BindingDB PrimarySearch

Found 2182 hits with Last Name = 'ng' and Initial = 'hl'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Adenylate cyclase type 4 (Homo sapiens (Human))	BDBM50226415 (CHEMBL3142312) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.880	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research and Development Division Curated by ChEMBL					Assay Description Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone				J Med Chem 30: 2291-4 (1987) BindingDB Entry DOI: 10.7270/Q2MG7RRN
Research and Development Division Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020671 (13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane				J Med Chem 29: 984-8 (1986) BindingDB Entry DOI: 10.7270/Q27M06W4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 4 (Homo sapiens (Human))	BDBM50226410 (CHEMBL3142318) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research and Development Division Curated by ChEMBL					Assay Description Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone				J Med Chem 30: 2291-4 (1987) BindingDB Entry DOI: 10.7270/Q2MG7RRN
Research and Development Division Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 4 (Homo sapiens (Human))	BDBM50226412 (CHEMBL3142332) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research and Development Division Curated by ChEMBL					Assay Description Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone				J Med Chem 30: 2291-4 (1987) BindingDB Entry DOI: 10.7270/Q2MG7RRN
Research and Development Division Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 4 (Homo sapiens (Human))	BDBM50226411 (CHEMBL3142329) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research and Development Division Curated by ChEMBL					Assay Description Binding affinity against sigma receptor				J Med Chem 30: 2291-4 (1987) BindingDB Entry DOI: 10.7270/Q2MG7RRN
Research and Development Division Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020669 (13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane				J Med Chem 29: 984-8 (1986) BindingDB Entry DOI: 10.7270/Q27M06W4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 4 (Homo sapiens (Human))	BDBM50226417 (CHEMBL3142331) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research and Development Division Curated by ChEMBL					Assay Description Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone				J Med Chem 30: 2291-4 (1987) BindingDB Entry DOI: 10.7270/Q2MG7RRN
Research and Development Division Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 4 (Homo sapiens (Human))	BDBM50226413 (CHEMBL2369777) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research and Development Division Curated by ChEMBL					Assay Description Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone				J Med Chem 30: 2291-4 (1987) BindingDB Entry DOI: 10.7270/Q2MG7RRN
Research and Development Division Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020665 (13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane				J Med Chem 29: 984-8 (1986) BindingDB Entry DOI: 10.7270/Q27M06W4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 4 (Homo sapiens (Human))	BDBM50226416 (CHEMBL2369525) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research and Development Division Curated by ChEMBL					Assay Description Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone				J Med Chem 30: 2291-4 (1987) BindingDB Entry DOI: 10.7270/Q2MG7RRN
Research and Development Division Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020654 (1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations.				J Med Chem 29: 2425-6 (1987) BindingDB Entry DOI: 10.7270/Q23T9G6Q
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020667 (1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane				J Med Chem 29: 984-8 (1986) BindingDB Entry DOI: 10.7270/Q27M06W4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 4 (Homo sapiens (Human))	BDBM50226414 (CHEMBL2369778) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research and Development Division Curated by ChEMBL					Assay Description Binding affinity against sigma receptor				J Med Chem 30: 2291-4 (1987) BindingDB Entry DOI: 10.7270/Q2MG7RRN
Research and Development Division Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020675 (1-[13-Benzyl-7-carbamoylmethyl-16-(4-ethoxy-benzyl...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations.				J Med Chem 29: 2425-6 (1987) BindingDB Entry DOI: 10.7270/Q23T9G6Q
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020666 (13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane				J Med Chem 29: 984-8 (1986) BindingDB Entry DOI: 10.7270/Q27M06W4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020673 (1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane				J Med Chem 29: 984-8 (1986) BindingDB Entry DOI: 10.7270/Q27M06W4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020653 (1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations.				J Med Chem 29: 2425-6 (1987) BindingDB Entry DOI: 10.7270/Q23T9G6Q
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 4 (Homo sapiens (Human))	BDBM50226418 (CHEMBL3142313) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	7.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research and Development Division Curated by ChEMBL					Assay Description Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone				J Med Chem 30: 2291-4 (1987) BindingDB Entry DOI: 10.7270/Q2MG7RRN
Research and Development Division Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020674 (1-[13-Benzyl-7-carbamoylmethyl-16-(4-ethoxy-benzyl...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations.				J Med Chem 29: 2425-6 (1987) BindingDB Entry DOI: 10.7270/Q23T9G6Q
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020672 (13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane				J Med Chem 29: 984-8 (1986) BindingDB Entry DOI: 10.7270/Q27M06W4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Sus scrofa)	BDBM50020668 (2-{[13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benz...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane				J Med Chem 29: 984-8 (1986) BindingDB Entry DOI: 10.7270/Q27M06W4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM8960 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Mixed-type inhibition of human AChE using acetylthiocholine chloride as substrate incubated for 5 mins followed by substrate addition by Lineweaver-B...				Eur J Med Chem 157: 161-176 (2018) Article DOI: 10.1016/j.ejmech.2018.08.005 BindingDB Entry DOI: 10.7270/Q29P34C1
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Vasopressin V2 receptor (Sus scrofa)	BDBM50020670 ((2-{[13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-ben...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane				J Med Chem 29: 984-8 (1986) BindingDB Entry DOI: 10.7270/Q27M06W4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50462868 (CHEMBL4251246) Show SMILES ONC(=O)CCOc1ccc(Cl)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Mixed-type inhibition of Helicobacter pylori ATCC 43504 urease assessed as enzyme-inhibitor complex using urea as substrate preincubated for 1.5 hrs				Bioorg Med Chem 26: 4145-4152 (2018) Article DOI: 10.1016/j.bmc.2018.07.003 BindingDB Entry DOI: 10.7270/Q2N87DFQ
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50462868 (CHEMBL4251246) Show SMILES ONC(=O)CCOc1ccc(Cl)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	54	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Mixed-type inhibition of Helicobacter pylori ATCC 43504 urease assessed as enzyme-substrate-inhibitor complex using urea as substrate preincubated fo...				Bioorg Med Chem 26: 4145-4152 (2018) Article DOI: 10.1016/j.bmc.2018.07.003 BindingDB Entry DOI: 10.7270/Q2N87DFQ
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Tetronarce californica (Pacific electric ray) (Tor...)	BDBM10441 ((+)-Huperzine A \| (+/-)Huperzine A \| (-)-Huperzine...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	175	-38.6	n/a	n/a	n/a	n/a	n/a	7.0	25
Weizmann Institute of Science					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...				Biochemistry 41: 10810-8 (2002) Article DOI: 10.1021/bi020151+ BindingDB Entry DOI: 10.7270/Q2HQ3X52
Weizmann Institute of Science					More data for this Ligand-Target Pair				3D Structure (crystal)
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM50196032 ((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of FAM-Bid BH3 peptide binding to recombinant human MCL1 by fluorescence polarization assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112201 BindingDB Entry DOI: 10.7270/Q26D5XMR
TBA					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM50196032 ((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of FAM-Bid BH3 peptide binding to recombinant human BCL2 by fluorescence polarization assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112201 BindingDB Entry DOI: 10.7270/Q26D5XMR
TBA					More data for this Ligand-Target Pair
Acetylcholinesterase (Tetronarce californica (Pacific electric ray) (Tor...)	BDBM10632 ((-)-Huperzine B \| (1R,10R)-16-methyl-6,14-diazatet...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	PDB Article PubMed	334	-37.0	n/a	n/a	n/a	n/a	n/a	7.0	25
Weizmann Institute of Science					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...				Biochemistry 41: 10810-8 (2002) Article DOI: 10.1021/bi020151+ BindingDB Entry DOI: 10.7270/Q2HQ3X52
Weizmann Institute of Science					More data for this Ligand-Target Pair				3D Structure (crystal)
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM50196032 ((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	1.11E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of FAM-Bid BH3 peptide binding to recombinant human BCL-XL by fluorescence polarization assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112201 BindingDB Entry DOI: 10.7270/Q26D5XMR
TBA					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50469009 (CHEMBL4292766) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Mixed-type inhibition of human AChE using acetylthiocholine chloride as substrate incubated for 5 mins followed by substrate addition by Lineweaver-B...				Eur J Med Chem 157: 161-176 (2018) Article DOI: 10.1016/j.ejmech.2018.08.005 BindingDB Entry DOI: 10.7270/Q29P34C1
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	1.42E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University at Buffalo Curated by ChEMBL					Assay Description Compound was tested for competitive antagonist of Nitric oxide synthase				Bioorg Med Chem Lett 10: 1077-80 (2000) BindingDB Entry DOI: 10.7270/Q2959GSN
University at Buffalo Curated by ChEMBL					More data for this Ligand-Target Pair
Cocaine esterase (Homo sapiens (Human))	BDBM50130903 (CHEMBL3632950) Show SMILES Show InChI	NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.76E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Liaoning University of Traditional Chinese Medicine Curated by ChEMBL					Assay Description Fixed inhibition of human carboxylesterase 2 using 4-benzoyl-N-butyl-1,8-naphthalimide as substrate by Dixon and Lineweaver-Burk plot analysis				J Nat Prod 78: 2372-80 (2015) Article DOI: 10.1021/acs.jnatprod.5b00321 BindingDB Entry DOI: 10.7270/Q20K2BDR
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50063300 ((L-N6-1-iminoethyl)lysine \| (S)-6-Acetimidoylamino...) Show SMILES CC(N)=NCCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	2.16E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University at Buffalo Curated by ChEMBL					Assay Description The compound was tested for competitive antagonist of Nitric oxide synthase				Bioorg Med Chem Lett 10: 1077-80 (2000) BindingDB Entry DOI: 10.7270/Q2959GSN
University at Buffalo Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50469008 (CHEMBL4283390) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Mixed-type inhibition of human AChE using acetylthiocholine chloride as substrate incubated for 5 mins followed by substrate addition by Lineweaver-B...				Eur J Med Chem 157: 161-176 (2018) Article DOI: 10.1016/j.ejmech.2018.08.005 BindingDB Entry DOI: 10.7270/Q29P34C1
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Tetronarce californica (Pacific electric ray) (Tor...)	BDBM10441 ((+)-Huperzine A \| (+/-)Huperzine A \| (-)-Huperzine...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	4.30E+3	-30.6	n/a	n/a	n/a	n/a	n/a	7.0	25
Weizmann Institute of Science					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...				Biochemistry 41: 10810-8 (2002) Article DOI: 10.1021/bi020151+ BindingDB Entry DOI: 10.7270/Q2HQ3X52
Weizmann Institute of Science					More data for this Ligand-Target Pair				3D Structure (crystal)
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50088667 (2-(S)-Amino-5-[(N-hydroxy-acetimidoyl)-amino]-pent...) Show SMILES CC(NCCC[C@H](N)C(O)=O)=NO \|w:11.11\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.77E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University at Buffalo Curated by ChEMBL					Assay Description The compound was tested for competitive antagonist of Nitric oxide synthase				Bioorg Med Chem Lett 10: 1077-80 (2000) BindingDB Entry DOI: 10.7270/Q2959GSN
University at Buffalo Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50088666 ((S)-2-Amino-6-[(N-hydroxy-acetimidoyl)-amino]-hexa...) Show SMILES CC(NCCCC[C@H](N)C(O)=O)=NO \|w:12.12\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4.11E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University at Buffalo Curated by ChEMBL					Assay Description The compound was tested for competitive antagonist of Nitric oxide synthase				Bioorg Med Chem Lett 10: 1077-80 (2000) BindingDB Entry DOI: 10.7270/Q2959GSN
University at Buffalo Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50517420 (CHEMBL4513589) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733 BindingDB Entry DOI: 10.7270/Q25X2D97
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM192642 (US9187486, 87) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0210	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM192574 (US9187486, 37 \| US9187486, 39 \| US9187486, 60) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0240	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM192574 (US9187486, 37 \| US9187486, 39 \| US9187486, 60) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0270	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Pim3 (unknown origin)				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50517433 (CHEMBL4450494) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733 BindingDB Entry DOI: 10.7270/Q25X2D97
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50517431 (CHEMBL4471849) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733 BindingDB Entry DOI: 10.7270/Q25X2D97
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM192648 (US9187486, 100) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM192640 (US9187486, 85) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50200531 (CHEMBL3950251) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50517428 (CHEMBL4568404) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733 BindingDB Entry DOI: 10.7270/Q25X2D97
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50517428 (CHEMBL4568404) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733 BindingDB Entry DOI: 10.7270/Q25X2D97
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50174153 (CHEMBL3808887) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...				ACS Med Chem Lett 7: 408-12 (2016) Article DOI: 10.1021/acsmedchemlett.5b00403 BindingDB Entry DOI: 10.7270/Q2MG7RD5
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

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