Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50005536 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1661741 (CHEMBL4011353) |
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Ki | 404±n/a nM |
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Citation | Tosh, DK; Janowsky, A; Eshleman, AJ; Warnick, E; Gao, ZG; Chen, Z; Gizewski, E; Auchampach, JA; Salvemini, D; Jacobson, KA Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. J Med Chem60:3109-3123 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | Dat | Dat1 | Dopamine transporter | SC6A3_MOUSE | Slc6a3 | Sodium-dependent dopamine transporter | Solute carrier family 6 member 3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 68809.06 |
Organism: | MOUSE |
Description: | Dopamine Transporter SLC6A3 MOUSE::Q61327 |
Residue: | 619 |
Sequence: | MSKSKCSVGPMSSVVAPAKEPNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEVQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDR
QLVDRGEVRQFTLRHWLLV
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BDBM50005536 |
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n/a |
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Name | BDBM50005536 |
Synonyms: | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol | 5-(4-chlorophenyl)-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol | 5-Thiophen-2-yl-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol | CHEMBL781 | MAZINDOL | Mazanor | Sanorex | mazindole |
Type | Small organic molecule |
Emp. Form. | C16H13ClN2O |
Mol. Mass. | 284.74 |
SMILES | OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1 |c:5| |
Structure |
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