| Reaction Details |
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 | Report a problem with these data |
| Target | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Ligand | BDBM292797 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1661915 (CHEMBL4011527) |
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| IC50 | 460±n/a nM |
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| Citation |  Dyck, B; Branstetter, B; Gharbaoui, T; Hudson, AR; Breitenbucher, JG; Gomez, L; Botrous, I; Marrone, T; Barido, R; Allerston, CK; Cedervall, EP; Xu, R; Sridhar, V; Barker, R; Aertgeerts, K; Schmelzer, K; Neul, D; Lee, D; Massari, ME; Andersen, CB; Sebring, K; Zhou, X; Petroski, R; Limberis, J; Augustin, M; Chun, LE; Edwards, TE; Peters, M; Tabatabaei, A Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties. J Med Chem60:3472-3483 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Name: | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE6C | PDE6C_HUMAN | PDEA2 | Phosphodiesterase 6C | Phosphodiesterase 6C (PDE6C) |
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| Type: | Protein |
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| Mol. Mass.: | 99132.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51160 |
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| Residue: | 858 |
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| Sequence: | MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML
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| BDBM292797 |
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| n/a |
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| Name | BDBM292797 |
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| Synonyms: | US10105367, Example 82 | US10376514, Example 82 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15ClN4OS |
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| Mol. Mass. | 370.856 |
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| SMILES | Clc1ccc(Cn2c3sc4CCCCc4c3c3ncnn3c2=O)cc1 |
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| Structure | 
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