Reaction Details |
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Target | Genome polyprotein [1658-1692] |
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Ligand | BDBM92628 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FRET-Based Assay |
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Temperature | 298.15±0 K |
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IC50 | 1.3e+3± 1e+2 nM |
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Citation | Saalau-Bethell, SM; Woodhead, AJ; Chessari, G; Carr, MG; Coyle, J; Graham, B; Hiscock, SD; Murray, CW; Pathuri, P; Rich, SJ; Richardson, CJ; Williams, PA; Jhoti, H Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function. Nat Chem Biol8:920-5 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Genome polyprotein [1658-1692] |
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Name: | Genome polyprotein [1658-1692] |
Synonyms: | NS3 Protein | Single chain N-terminally linked NS4a 21-32 NS3 3-631 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Genome polyprotein |
Synonyms: | Hepatitis C virus NS3 protease/helicase | Hepatitis C virus serine protease, NS3/NS4A |
Type: | Protein |
Mol. Mass.: | 67067.41 |
Organism: | Hepatitis C virus |
Description: | A3EZI9 |
Residue: | 631 |
Sequence: | APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAG
TRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRG
DGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMR
SPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGA
YMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSI
LGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIK
GGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTG
DFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGE
RPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLT
HIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLY
RLGAVQNEITLTHPITKYIMTCMSADLEVVT
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Component 2 |
Name: | Genome polyprotein [1658-1692] |
Synonyms: | NS4A Protein | POLG_HCVTW |
Type: | Protein |
Mol. Mass.: | 3488.19 |
Organism: | Hepatitis C virus |
Description: | F4YQW6 |
Residue: | 35 |
Sequence: | STWVLVGGVL AALAAYCLTT GSVVIVGRII LSGKP
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BDBM92628 |
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n/a |
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Name | BDBM92628 |
Synonyms: | (1R)-1-(2,4-difluoro-3-phenoxyphenyl)propan-1-amine, 4 |
Type | Small molecule |
Emp. Form. | C15H15ClFNO |
Mol. Mass. | 279.737 |
SMILES | CC[C@@H](N)c1ccc(Cl)c(Oc2ccccc2)c1F |r| |
Structure |
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