| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM102143 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLIPR Assay |
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| pH | 7.4±0 |
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| Ki | 365±n/a nM |
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| Citation |  Badiger, S; Behnke, D; Betschart, C; Chaudhari, V; Cotesta, S; Hinrichs, JH; Ofner, S; Pandit, C; Wagner, J Diaza-spiro[5.5]undecanes US Patent US8530648 Publication Date 9/10/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
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| Type: | Protein |
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| Mol. Mass.: | 47554.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43613 |
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| Residue: | 425 |
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| Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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| BDBM102143 |
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| n/a |
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| Name | BDBM102143 |
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| Synonyms: | US8530648, 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N5O |
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| Mol. Mass. | 439.5521 |
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| SMILES | Cc1cc2c(CN3CCCC4(CCN(CC4)c4cnc5ccccc5n4)C3=O)cccc2[nH]1 |
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| Structure | 
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