Reaction Details |
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Target | Cyclin-dependent kinase 2 |
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Ligand | BDBM105243 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Kinase Assay |
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pH | 8±0 |
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IC50 | 5.6e+3±n/a nM |
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Citation | Guzi, TJ; Paruch, K; Dwyer, MP; Labroli, MA; Keertikar, KM Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors US Patent US8580782 Publication Date 11/12/2013 |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cyclin-dependent kinase 2 |
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Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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BDBM105243 |
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n/a |
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Name | BDBM105243 |
Synonyms: | US8580782, 17 |
Type | Small organic molecule |
Emp. Form. | C17H21N7 |
Mol. Mass. | 323.3955 |
SMILES | CN1CCN(CC1)c1cc(NCc2cccnc2)n2nccc2n1 |
Structure |
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