Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM119654 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Radioligand Binding |
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Temperature | 277.15±n/a K |
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Ki | 20±n/a nM |
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Comments | extracted |
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Citation | Branstetter, BJ; Letavic, MA; Ly, KS; Rudolph, DA; Savall, BM; Shah, CR; Shireman, BT Fused heterocyclic compounds as orexin receptor modulators US Patent US8680275 Publication Date 3/25/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM119654 |
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n/a |
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Name | BDBM119654 |
Synonyms: | US8680275, 23 |
Type | Small organic molecule |
Emp. Form. | C23H23FN6O |
Mol. Mass. | 418.4667 |
SMILES | Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1cc(F)ccc1-c1ncccn1 |
Structure |
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