Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 | ||
Ligand | BDBM141466 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 8±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1.6±n/a nM | ||
Comments | extracted | ||
Citation | Wrobleski, ST; Brown, GD; Doweyko, LM; Duan, J; Guo, J; Hynes, J; Jiang, B; Kempson, J; Lin, S; Lu, Z; Spergel, SH; Tokarski, JS; Wu, H; Yang, BV Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases US Patent US8921368 Publication Date 12/30/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 | |||
Name: | Tyrosine-protein kinase JAK3 | ||
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
Type: | Protein | ||
Mol. Mass.: | 125111.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333 | ||
Residue: | 1124 | ||
Sequence: |
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BDBM141466 | |||
n/a | |||
Name | BDBM141466 | ||
Synonyms: | US8921368, 167 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H23N5O2 | ||
Mol. Mass. | 389.4503 | ||
SMILES | C[C@@]1(O)CC[C@@H](CC1)Nc1c(cnn2cc(cc12)-c1ccc(cc1)[N+]#[C-])C(N)=O |r,wU:5.8,1.1,wD:1.0,(-1.63,3.47,;-.3,2.69,;-.3,4.23,;-.3,1.15,;1.03,.38,;2.37,1.15,;2.37,2.69,;1.03,3.47,;3.7,.38,;3.7,-1.15,;5.03,-1.93,;5.03,-3.47,;3.7,-4.23,;2.37,-3.47,;.9,-3.94,;-0,-2.69,;.9,-1.45,;2.37,-1.93,;-1.54,-2.69,;-2.31,-1.36,;-3.85,-1.36,;-4.68,-2.69,;-3.85,-4.03,;-2.31,-4.03,;-6.22,-2.69,;-7.76,-2.69,;6.37,-1.15,;7.7,-1.93,;6.37,.38,)| | ||
Structure |