Reaction Details |
| Report a problem with these data |
Target | E3 ubiquitin-protein ligase Mdm2 |
---|
Ligand | BDBM143533 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay |
---|
IC50 | 0.242±n/a nM |
---|
Citation | Furet, P; Guagnano, V; Holzer, P; Mah, R; Masuya, K; Schlapbach, A; Stutz, S; Vaupel, A Pyrazolopyrrolidine compounds US Patent US8969341 Publication Date 3/3/2015 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
E3 ubiquitin-protein ligase Mdm2 |
---|
Name: | E3 ubiquitin-protein ligase Mdm2 |
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
Type: | Oncoprotein |
Mol. Mass.: | 55196.54 |
Organism: | Homo sapiens (Human) |
Description: | Q00987 |
Residue: | 491 |
Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
|
|
|
BDBM143533 |
---|
n/a |
---|
Name | BDBM143533 |
Synonyms: | US8969341, 136 |
Type | Small organic molecule |
Emp. Form. | C30H24ClN5O2 |
Mol. Mass. | 521.997 |
SMILES | COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)[N+]#[C-])c1cc(Cl)ccc1C)C#N |
Structure |
|