| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 4 |
|---|
| Ligand | BDBM152479 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | HDAC Enzyme Activity Assay |
|---|
| IC50 | 18±0.0 nM |
|---|
| Citation |  Shahidul Islam, M; Nurul Islam, M; Ashraful Hoque, M; Nishino, N; Kato, T; Kim, HJ; Ito, A; Yoshida, M An efficient synthesis of SK-658 and its analogs as potent histone deacetylase inhibitors. Bioorg Chem59:145-50 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 4 |
|---|
| Name: | Histone deacetylase 4 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 4 | HD4 | HDAC4 | HDAC4_HUMAN | Histone acetylase 4(HDAC4) | Human HDAC4 | KIAA0288 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 119049.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P56524 |
|---|
| Residue: | 1084 |
|---|
| Sequence: | MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
EPPL
|
|
|
|---|
| BDBM152479 |
|---|
| n/a |
|---|
| Name | BDBM152479 |
|---|
| Synonyms: | Z-L-Am7(Ac)-QA (1) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H29N3O4S |
|---|
| Mol. Mass. | 479.591 |
|---|
| SMILES | CC(=O)SCCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2cccnc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
