| Reaction Details |
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 | Report a problem with these data |
| Target | Replicase polyprotein 1ab [1541-1855] |
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| Ligand | BDBM154573 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorimetric Assay |
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| pH | 7.5±n/a |
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| Ki | 1.15e+4±n/a nM |
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| IC50 | 1.09e+4± 9e+2 nM |
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| Comments | extracted |
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| Citation |  Lee, H; Lei, H; Santarsiero, BD; Gatuz, JL; Cao, S; Rice, AJ; Patel, K; Szypulinski, MZ; Ojeda, I; Ghosh, AK; Johnson, ME Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV. ACS Chem Biol10:1456-65 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Replicase polyprotein 1ab [1541-1855] |
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| Name: | Replicase polyprotein 1ab [1541-1855] |
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| Synonyms: | R1AB_SARS | SARS Coronavirus Coronavirus Papain-Like Protease | SARS-CoV PLpro | SARS-CoV papain-like protease (SARS-PLpro) | rep |
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| Type: | Hydrolase |
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| Mol. Mass.: | 35352.30 |
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| Organism: | Human SARS coronavirus (SARS-CoV) |
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| Description: | The SARS-CoV PLpro enzyme (residues 1541 -1855) was expressed and purified from E. coli. |
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| Residue: | 315 |
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| Sequence: | EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPS
DDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLAL
QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLES
AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS
FVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPV
TDVFYKETSYTTTIK
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| BDBM154573 |
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| n/a |
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| Name | BDBM154573 |
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| Synonyms: | 8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jmedchem.1c00409_ST.555 | jm5b01461, Compound 188 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H4F3N5 |
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| Mol. Mass. | 203.1247 |
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| SMILES | Nc1ncnc2[nH]c(nc12)C(F)(F)F |
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| Structure | 
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