| Reaction Details |
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 | Report a problem with these data |
| Target | AMP deaminase 1 |
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| Ligand | BDBM154584 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AMPD Enzymatic Activity Assay |
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| pH | 7.4±n/a |
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| IC50 | 20±n/a nM |
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| Comments | extracted |
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| Citation |  Admyre, T; Amrot-Fors, L; Andersson, M; Bauer, M; Bjursell, M; Drmota, T; Hallen, S; Hartleib-Geschwindner, J; Lindmark, B; Liu, J; Löfgren, L; Rohman, M; Selmi, N; Wallenius, K Inhibition of AMP deaminase activity does not improve glucose control in rodent models of insulin resistance or diabetes. Chem Biol21:1486-96 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| AMP deaminase 1 |
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| Name: | AMP deaminase 1 |
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| Synonyms: | AMP deaminase 1 (rAMPD1) | AMPD1_RAT | Ampd1 |
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| Type: | Protein |
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| Mol. Mass.: | 86437.40 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | n/a |
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| Residue: | 747 |
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| Sequence: | MPLFKLTGQGKQIDDAMRSFAEKVFASEVKDEGGRHEISPFDVDEICPISLREMQAHIFH
MENLSMSMDGRRKRRFQGRKTVNLSIPQSETSSTKLSHIEEFISSSPTYESVPDFQRVQI
TGDYASGVTVEDFEVVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEALVAIESF
YPVFTPPPKKGEDPFRREDLPANLGYHLKMKGGVIYIYPDEAAASRDEPKPYPYPNLDDF
LDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKV
DTHIHAAACMNQKHLLRFIKKSYHIDADRVVYSTKEKNLTLKELFAQLNMHPYDLTVDSL
DVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVDAKYQ
HAEPRLSIYGRSPDEWSKLSSWFVGNRIYCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLE
NIFLPVFEATINPQTHPDLSVFLKHITGFDSVDDESKHSGHMFSSKSPKPEEWTMENNPS
YTYYAYYMYANIMVLNCLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADNISHGLNLKK
SPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEP
LMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKAKFLGNNYLEEGPVGNDIRRTNV
AQIRMAYRYETWCYELNLIAEGLKSTE
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| BDBM154584 |
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| n/a |
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| Name | BDBM154584 |
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| Synonyms: | 4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methyl)phenyl]-2-methoxybenzoic acid (Compound 4) |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24N2O3 |
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| Mol. Mass. | 412.4804 |
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| SMILES | COc1cc(ccc1C(O)=O)-c1ccc(CN[C@H](C)c2cccc3ccncc23)cc1 |r| |
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| Structure | 
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