| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor XIII A chain [Q652E] |
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| Ligand | BDBM185173 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TG Activity Assays |
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| IC50 | 3.7e+4±n/a nM |
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| Citation |  Badarau, E; Wang, Z; Rathbone, DL; Costanzi, A; Thibault, T; Murdoch, CE; El Alaoui, S; Bartkeviciute, M; Griffin, M Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological Conditions. Chem Biol22:1347-61 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor XIII A chain [Q652E] |
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| Name: | Coagulation factor XIII A chain [Q652E] |
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| Synonyms: | Coagulation factor XIII A (FXIIIa) | F13A | F13A1 | F13A_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 83261.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00488[Q652E] |
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| Residue: | 732 |
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| Sequence: | MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVEFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM
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| BDBM185173 |
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| n/a |
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| Name | BDBM185173 |
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| Synonyms: | N-[2-[4-(adamantane-1-carbonyl)piperazin-1-yl]-2-oxo-ethyl]prop-2-enamide (3e) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H29N3O3 |
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| Mol. Mass. | 359.4626 |
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| SMILES | C=CC(=O)NCC(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:19:20:24:18.23.17,23:18:25:22.24.21,23:22:25:19.18.17,THB:19:18:24:25.20.21| |
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| Structure | 
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