| Reaction Details |
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 | Report a problem with these data |
| Target | G-protein coupled estrogen receptor 1 |
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| Ligand | BDBM288608 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| IC50 | 0.640±n/a nM |
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| Citation |  Yu, S; Yang, F; Chen, L; Yan, J; Zhang, X; Xie, Z; Chen, L; He, M Piperidine derivative and preparation method and pharmaceutical use thereof US Patent US10087191 Publication Date 10/2/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| G-protein coupled estrogen receptor 1 |
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| Name: | G-protein coupled estrogen receptor 1 |
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| Synonyms: | CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42259.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_982507 |
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| Residue: | 375 |
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| Sequence: | MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLF
LSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLH
ERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL
IWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRV
LVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRH
AHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVI
PDSTEQSDVRFSSAV
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| BDBM288608 |
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| n/a |
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| Name | BDBM288608 |
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| Synonyms: | (E)-3-(3,5-difluoro-4-((1S,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-6-(2-methylthiazol-5-yl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phenyl)acrylic acid | US10087191, Example 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27F3N2O2S |
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| Mol. Mass. | 500.576 |
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| SMILES | C[C@@H]1Cc2cc(ccc2[C@H](N1CC(C)(C)F)c1c(F)cc(\C=C\C(O)=O)cc1F)-c1cnc(C)s1 |r| |
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| Structure | 
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