Reaction Details |
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Target | G-protein coupled estrogen receptor 1 |
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Ligand | BDBM288684 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biological Assay |
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IC50 | 0.640±n/a nM |
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Citation | Yu, S; Yang, F; Chen, L; Yan, J; Zhang, X; Xie, Z; Chen, L; He, M Piperidine derivative and preparation method and pharmaceutical use thereof US Patent US10087191 Publication Date 10/2/2018 |
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More Info.: | Get all data from this article, Assay Method |
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G-protein coupled estrogen receptor 1 |
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Name: | G-protein coupled estrogen receptor 1 |
Synonyms: | CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30 |
Type: | PROTEIN |
Mol. Mass.: | 42259.21 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_982507 |
Residue: | 375 |
Sequence: | MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLF
LSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLH
ERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL
IWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRV
LVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRH
AHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVI
PDSTEQSDVRFSSAV
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BDBM288684 |
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n/a |
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Name | BDBM288684 |
Synonyms: | (E)-3-(4-((6R,8R/6S,8S)-7-isobutyl-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)phenyl)acrylic acid | US10087191, Example 102 |
Type | Small organic molecule |
Emp. Form. | C24H27N3O2 |
Mol. Mass. | 389.4901 |
SMILES | CC(C)CN1C(C)Cc2c(ccc3[nH]ncc23)C1c1ccc(\C=C\C(O)=O)cc1 |
Structure |
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