| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM203833 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AChE and BuChE Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 45± 2e+1 nM |
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| Comments | extracted |
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| Citation |  Leng, J; Qin, HL; Zhu, K; Jantan, I; Hussain, MA; Sher, M; Amjad, MW; Naeem-Ul-Hassan, M; Ahmad, W; Bukhari, SN Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease. Chem Biol Drug Des88:889-898 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache |
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| Type: | Enzyme |
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| Mol. Mass.: | 71812.79 |
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| Organism: | Electrophorus electricus (Electric eel) |
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| Description: | n/a |
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| Residue: | 633 |
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| Sequence: | MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFA
EPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLY
LNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGF
LALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDS
RPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLI
DQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYG
APGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIV
GDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHR
ASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINV
DGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAE
RQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
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| BDBM203833 |
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| n/a |
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| Name | BDBM203833 |
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| Synonyms: | 2-(2-Bromo-3,4,5-trimethoxy-benzylidene)-4-methyl-tetralone (3f) |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21BrO4 |
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| Mol. Mass. | 417.293 |
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| SMILES | COc1cc(\C=C2/CC(C)c3ccccc3C2=O)c(Br)c(OC)c1OC |
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| Structure | 
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