| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
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| Ligand | BDBM203858 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Monoamine Oxidase Assay |
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| pH | 7.4±n/a |
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| Temperature | 311.15±n/a K |
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| IC50 | 7.23e+3± 1.2e+3 nM |
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| Comments | extracted |
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| Citation |  Leng, J; Qin, HL; Zhu, K; Jantan, I; Hussain, MA; Sher, M; Amjad, MW; Naeem-Ul-Hassan, M; Ahmad, W; Bukhari, SN Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease. Chem Biol Drug Des88:889-898 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] A |
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| Name: | Amine oxidase [flavin-containing] A |
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| Synonyms: | AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59515.21 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 526 |
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| Sequence: | MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV
KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA
YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI
NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL
SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM
GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR
QAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD
VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
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| BDBM203858 |
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| n/a |
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| Name | BDBM203858 |
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| Synonyms: | (2E)-2-[(2-chloro-3-methoxyphenyl)methylidene]-7-nitro-1,2,3,4-tetrahydronaphthalen-1-one (3ae) |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14ClNO4 |
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| Mol. Mass. | 343.761 |
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| SMILES | COc1cccc(\C=C2/CCc3ccc(cc3C2=O)[N+]([O-])=O)c1Cl |
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| Structure | 
|
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