| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
|---|
| Ligand | BDBM203831 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Monoamine Oxidase Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 311.15±n/a K |
|---|
| IC50 | 3.2e+3± 1.2e+3 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Leng, J; Qin, HL; Zhu, K; Jantan, I; Hussain, MA; Sher, M; Amjad, MW; Naeem-Ul-Hassan, M; Ahmad, W; Bukhari, SN Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease. Chem Biol Drug Des88:889-898 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Amine oxidase [flavin-containing] B |
|---|
| Name: | Amine oxidase [flavin-containing] B |
|---|
| Synonyms: | AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 58469.65 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P19643 |
|---|
| Residue: | 520 |
|---|
| Sequence: | MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWR
TMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQ
TGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVY
YKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEER
LRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGK
IFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNT
FLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
|
|
|
|---|
| BDBM203831 |
|---|
| n/a |
|---|
| Name | BDBM203831 |
|---|
| Synonyms: | (2E)-2-[(2-chloro-3-methoxyphenyl)methylidene]-4-methyl-1,2,3,4-tetrahydronaphthalen-1-one (3d) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17ClO2 |
|---|
| Mol. Mass. | 312.79 |
|---|
| SMILES | COc1cccc(\C=C2/CC(C)c3ccccc3C2=O)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
