| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 11B |
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| Ligand | BDBM205483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Competitive Binding Assay (KINOMEscan) |
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| Kd | 7500±n/a nM |
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| Citation |  Murphy, EA; Cheresh, DA; Arnold, LD Therapeutic methods and compositions involving allosteric kinase inhibition US Patent US9260417 Publication Date 2/16/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 11B |
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| Name: | Cyclin-dependent kinase 11B |
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| Synonyms: | 2.7.11.22 | CD11B_HUMAN | CDC2L1 | CDK11 | CDK11B | CLK-1 | Cell division cycle 2-like protein kinase 1 | Cell division protein kinase 11B | Cyclin-dependent kinase | Cyclin-dependent kinase 11 (CDK11) | Cyclin-dependent kinase 11B | Galactosyltransferase-associated protein kinase p58/GTA | PITSLRE serine/threonine-protein kinase CDC2L1 | PITSLREA | PK58 | p58 CLK-1 |
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| Type: | Protein |
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| Mol. Mass.: | 92685.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21127 |
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| Residue: | 795 |
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| Sequence: | MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
ERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG
SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED
EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ
ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI
TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK
TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT
LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK
IWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH
EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT
NQGASAAGPGFSLKF
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| BDBM205483 |
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| n/a |
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| Name | BDBM205483 |
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| Synonyms: | US9260417, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16F3N7OS |
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| Mol. Mass. | 459.448 |
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| SMILES | CSc1nc(N)cc(Oc2ccc(cc2)-c2nnc(Nc3cccc(c3)C(F)(F)F)[nH]2)n1 |
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| Structure | 
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