Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM208519 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Antagonistic Activity Assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 0.8±n/a nM |
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Comments | extracted |
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Citation | Futamura, A; Araki, Y; Abe, M; Ohta, H; Suzuki, R; Nozawa, D Heteroaromatic methyl cyclic amine derivative US Patent US9266870 Publication Date 2/23/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM208519 |
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n/a |
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Name | BDBM208519 |
Synonyms: | US9266870, 35 |
Type | Small organic molecule |
Emp. Form. | C24H23FN6O2 |
Mol. Mass. | 446.4768 |
SMILES | Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-n1nccn1 |
Structure |
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