Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM208519 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Antagonistic Activity Assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 1±n/a nM |
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Comments | extracted |
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Citation | Futamura, A; Araki, Y; Abe, M; Ohta, H; Suzuki, R; Nozawa, D Heteroaromatic methyl cyclic amine derivative US Patent US9266870 Publication Date 2/23/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM208519 |
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n/a |
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Name | BDBM208519 |
Synonyms: | US9266870, 35 |
Type | Small organic molecule |
Emp. Form. | C24H23FN6O2 |
Mol. Mass. | 446.4768 |
SMILES | Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-n1nccn1 |
Structure |
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