Reaction Details | |||
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Target | Bromodomain-containing protein 4 [352-457] | ||
Ligand | BDBM220679 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Bromodomain Domain Binding Assay | ||
pH | 6±n/a | ||
Temperature | 298.15±n/a K | ||
Ki | 0.57±n/a nM | ||
Comments | extracted | ||
Citation | Wang, L; Pratt, JK; McDaniel, KF; Dai, Y; Fidanze, SD; Hasvold, L; Holms, JH; Kati, WM; Liu, D; Mantei, RA; McClellan, WJ; Sheppard, GS; Wada, CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Bromodomain-containing protein 4 [352-457] | |||
Name: | Bromodomain-containing protein 4 [352-457] | ||
Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 352-457) | Bromodomain-containing protein 4 (BRD4-BD2) | HUNK1 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 12432.37 | ||
Organism: | Homo sapiens (Human) | ||
Description: | BDII: amino acid E352-M457 | ||
Residue: | 106 | ||
Sequence: |
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BDBM220679 | |||
n/a | |||
Name | BDBM220679 | ||
Synonyms: | US9296741, 268 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H30N2O5S | ||
Mol. Mass. | 458.57 | ||
SMILES | CCS(=O)(=O)c1ccc(OC2CCC(C)(CC2)OC)c(c1)-c1cn(C)c(=O)c2[nH]ccc12 |(5.69,1.13,;6.46,2.46,;5.69,3.8,;4.92,5.13,;7.03,4.57,;4.36,3.03,;3.03,3.8,;1.69,3.03,;1.69,1.49,;.36,.72,;-.97,1.49,;-2.31,.72,;-3.64,1.49,;-3.64,3.03,;-5.18,3.08,;-2.31,3.8,;-.97,3.03,;-4.46,4.33,;-6,4.28,;3.03,.72,;4.36,1.49,;3.03,-.82,;4.36,-1.59,;4.36,-3.13,;5.69,-3.9,;3.03,-3.9,;3.03,-5.44,;1.69,-3.13,;.23,-3.61,;-.68,-2.36,;.23,-1.12,;1.69,-1.59,)| | ||
Structure |