Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231111

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

5.17±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231111

n/a

Name

BDBM231111

Synonyms:

US9340549, 136

Type

Small organic molecule

Emp. Form.

C24H27N3O2

Mol. Mass.

389.4901

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)C1CC[C@@H](CC1)c1cnc2[nH]ccc2c1 |r,wU:7.8,wD:17.22,(-7.31,.02,;-5.97,.79,;-6.74,-.54,;-5.97,2.33,;-4.51,2.81,;-3.74,4.14,;-3.6,1.56,;-4.51,.32,;-4.11,-1.17,;-5.2,-2.26,;-4.8,-3.75,;-3.31,-4.14,;-2.22,-3.05,;-2.62,-1.57,;-2.06,1.56,;-1.29,2.9,;.25,2.9,;1.02,1.56,;.25,.23,;-1.29,.23,;2.56,1.56,;3.33,2.9,;4.87,2.9,;5.64,1.56,;7.14,1.24,;7.31,-.29,;5.9,-.91,;4.87,.23,;3.33,.23,)|

Structure