Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231141

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

>46300±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231141

n/a

Name

BDBM231141

Synonyms:

US9340549, 166

Type

Small organic molecule

Emp. Form.

C22H27N3O3S

Mol. Mass.

413.533

SMILES

Cc1nc(cs1)C(=O)N[C@H]1CC[C@@H](CC1)N1[C@@H](c2ccccc2)C(C)(C)OC1=O |r,wU:16.18,9.9,wD:12.16,(7.94,1.31,;6.6,2.08,;5.14,1.61,;4.23,2.85,;5.14,4.1,;6.6,3.62,;2.69,2.85,;1.93,4.19,;1.93,1.52,;.38,1.52,;-.38,.19,;-1.93,.19,;-2.69,1.52,;-1.93,2.85,;-.38,2.85,;-4.23,1.52,;-5.14,.27,;-4.74,-1.21,;-5.83,-2.3,;-5.43,-3.79,;-3.94,-4.19,;-2.86,-3.1,;-3.25,-1.61,;-6.6,.75,;-7.94,-.02,;-7.37,-.58,;-6.6,2.29,;-5.14,2.77,;-4.37,4.1,)|

Structure