Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231152

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

1.01±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231152

n/a

Name

BDBM231152

Synonyms:

US9340549, 174

Type

Small organic molecule

Emp. Form.

C28H29N5O2

Mol. Mass.

467.5622

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@H](CC1)c1cnc2ccn(-c3ncccn3)c2c1 |r,wU:7.8,wD:14.15,17.22,(-6.93,-3.44,;-6.16,-2.11,;-5.39,-3.44,;-7.06,-.86,;-6.16,.38,;-6.93,1.72,;-4.69,-.09,;-4.69,-1.63,;-3.6,-2.72,;-4,-4.21,;-2.91,-5.3,;-1.42,-4.9,;-1.03,-3.41,;-2.11,-2.32,;-3.36,.68,;-2.02,-.09,;-.69,.68,;-.69,2.22,;-2.02,2.99,;-3.36,2.22,;.64,2.99,;.64,4.53,;1.98,5.3,;3.31,4.53,;4.78,5,;5.68,3.76,;4.78,2.51,;5.17,1.02,;4.09,-.06,;4.48,-1.55,;5.97,-1.95,;7.06,-.86,;6.66,.63,;3.31,2.99,;1.98,2.22,)|

Structure