Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231157

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

1020±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231157

n/a

Name

BDBM231157

Synonyms:

US9340549, 177

Type

Small organic molecule

Emp. Form.

C23H23N3O3

Mol. Mass.

389.447

SMILES

CC1(C)OC(=O)N([C@H]2CC(C2)c2nnc(o2)-c2ccccc2)[C@H]1c1ccccc1 |r,wU:22.26,7.6,(-7.13,-1.48,;-6.36,-.14,;-7.69,-.91,;-6.83,1.32,;-5.59,2.23,;-5.59,3.77,;-4.34,1.32,;-2.85,1.72,;-2.08,3.05,;-.75,2.28,;-1.52,.95,;.74,2.68,;1.21,4.15,;2.75,4.15,;3.23,2.68,;1.98,1.78,;4.72,2.28,;5.11,.79,;6.6,.4,;7.69,1.49,;7.29,2.97,;5.81,3.37,;-4.82,-.14,;-4.05,-1.48,;-4.82,-2.81,;-4.05,-4.15,;-2.51,-4.15,;-1.74,-2.81,;-2.51,-1.48,)|

Structure