Ki Summary

Reaction Details

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Target

Bcl-2-like protein 1

Ligand

BDBM50384329

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Resonance Energy Transfer Assay (FRET)

Temperature

298.15±n/a K

IC50

10±n/a nM

Comments

extracted

Citation

Borzilleri, RM; Cai, Z; Tebben, AJ; Perez, HL; Zhang, L; Schroeder, GM; Wei, DD Substituted sulfonamides useful as antiapoptotic Bcl inhibitors US Patent US9346795 Publication Date 5/24/2016

More Info.:

Get all data from this article, Assay Method

Bcl-2-like protein 1

Name:

Bcl-2-like protein 1

Synonyms:

Type:

Mitochondrion membrane; Single-pass membrane protein

Mol. Mass.:

26039.60

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

233

Sequence:

MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK

BDBM50384329

n/a

Name

BDBM50384329

Synonyms:

CHEMBL2030864 | US9346795, 252

Type

Small organic molecule

Emp. Form.

C47H40Cl2N4O6S

Mol. Mass.

859.815

SMILES

CCCCc1c(c(CO)nn1-c1ccc(Oc2cccc(Cl)c2)cc1)-c1ccc(cc1C(=O)N1CCc2ccccc2C1)C(=O)NS(=O)(=O)c1ccc2cccc(Cl)c2c1 |(-.35,-2.86,;.94,-3.7,;2.31,-3,;2.4,-1.46,;3.78,-.76,;5.2,-.17,;5.07,1.37,;6.24,2.37,;5.96,3.88,;3.58,1.72,;2.77,.41,;1.24,.4,;.46,1.73,;-1.08,1.72,;-1.84,.38,;-3.38,.36,;-4.16,1.69,;-5.7,1.67,;-6.48,2.99,;-5.73,4.34,;-4.19,4.35,;-3.43,5.69,;-3.41,3.02,;-1.05,-.96,;.48,-.94,;6.51,-.97,;7.86,-.24,;9.19,-1.04,;9.14,-2.59,;7.79,-3.32,;6.47,-2.51,;5.12,-3.24,;3.81,-2.43,;5.07,-4.78,;3.72,-5.51,;3.68,-7.04,;4.98,-7.85,;4.93,-9.38,;6.24,-10.2,;7.59,-9.48,;7.65,-7.93,;6.34,-7.13,;6.39,-5.58,;10.45,-3.39,;11.81,-2.66,;10.41,-4.93,;11.73,-5.75,;10.95,-7.08,;12.49,-7.08,;13.07,-4.99,;13.1,-3.45,;14.44,-2.69,;15.76,-3.47,;17.11,-2.71,;18.44,-3.49,;18.43,-5.05,;17.08,-5.81,;17.06,-7.35,;15.75,-5.02,;14.4,-5.78,)|

Structure