| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TBK1 |
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| Ligand | BDBM245952 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Time-Resolved Fluorescence-based Lanthascreen Assay |
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| pH | 7.5±n/a |
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| IC50 | <15±n/a nM |
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| Comments | extracted |
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| Citation |  Newton, GK; Stewart, MR; Perrior, TR; Crosby, SR; Hopkins, A; Negoita-Giras, G; Jenkins, K Pyrimidine compounds useful in the treatment of diseases mediated by IKKE and/or TBK1 mechanisms US Patent US9433622 Publication Date 9/6/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase TBK1 |
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| Name: | Serine/threonine-protein kinase TBK1 |
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| Synonyms: | NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN |
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| Type: | protein |
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| Mol. Mass.: | 83645.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UHD2 |
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| Residue: | 729 |
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| Sequence: | MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
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| BDBM245952 |
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| n/a |
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| Name | BDBM245952 |
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| Synonyms: | US9433622, DMX- 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26FN9 |
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| Mol. Mass. | 459.5219 |
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| SMILES | CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cnc(N3CC[C@H](F)C3)c(c2)C#N)cn1 |r| |
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| Structure | 
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