| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM254402 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radioligand Binding Assay |
|---|
| Ki | 5±n/a nM |
|---|
| Citation |  Alcazar Vaca, MJ; Andres Gil, JI; Chrovian, CC; Coate, HR; De Angelis, M; Dvorak, CA; Gelin, CF; Letavic, MA; Savall, BM; Soyode-Johnson, A; Stenne, BM; Swanson, DM P2X7 modulators US Patent US9464084 Publication Date 10/11/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68602.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q99572 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
|
|
|
|---|
| BDBM254402 |
|---|
| n/a |
|---|
| Name | BDBM254402 |
|---|
| Synonyms: | US10112937, Example 310 | US10150765, Example 310 | US10703749, Example 310 | US9464084, 310 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H16ClF3N6O |
|---|
| Mol. Mass. | 424.807 |
|---|
| SMILES | C[C@H]1Cc2c(nnn2-c2ccn[nH]2)[C@@H](C)N1C(=O)c1cccc(c1Cl)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
