Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM259632

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Assay

IC50

0.148±n/a nM

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM259632

n/a

Name

BDBM259632

Synonyms:

US9505749, 145

Type

Small organic molecule

Emp. Form.

C25H24FN5O3S

Mol. Mass.

493.553

SMILES

Fc1ccc2nc(SCCC(=O)N[C@H]3CC[C@@H](CC3)c3nnc(o3)-c3ccccc3)[nH]c(=O)c2c1 |r,wU:13.12,wD:16.19,(-11.1,5.33,;-10.33,4,;-11.1,2.67,;-10.33,1.33,;-8.79,1.33,;-8.02,,;-6.48,,;-5.71,-1.33,;-4.17,-1.33,;-3.4,-2.67,;-1.86,-2.67,;-1.09,-1.33,;-1.09,-4,;.45,-4,;1.22,-2.67,;2.76,-2.67,;3.53,-4,;2.76,-5.33,;1.22,-5.33,;5.07,-4,;5.97,-5.25,;7.44,-4.77,;7.44,-3.23,;5.97,-2.76,;8.53,-2.14,;10.01,-2.54,;11.1,-1.45,;10.7,.04,;9.22,.43,;8.13,-.65,;-5.71,1.33,;-6.48,2.67,;-5.71,4,;-8.02,2.67,;-8.79,4,)|

Structure