Reaction Details |
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Target | TGF-beta receptor type-1 [4-503,T204D] |
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Ligand | BDBM412738 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biological Assays |
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IC50 | 0.420±n/a nM |
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Citation | Harikrishnan, LS; Fink, BE; Borzilleri, RM; Tonukunuru, G; Sankara Warrier, J TGF beta receptor antagonists US Patent US10399987 Publication Date 9/3/2019 |
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More Info.: | Get all data from this article, Assay Method |
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TGF-beta receptor type-1 [4-503,T204D] |
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Name: | TGF-beta receptor type-1 [4-503,T204D] |
Synonyms: | ALK5 | SKR4 | TGF-beta receptor type-1 T204D | TGFBR1 | TGFR-1 T204D | TGFR1_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 55650.84 |
Organism: | Homo sapiens (Human) |
Description: | P36897 T204D |
Residue: | 500 |
Sequence: | AVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTD
KVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGP
VELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYD
MTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWF
REAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMI
KLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATD
TIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHED
YQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARL
TALRIKKTLSQLSQQEGIKM
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BDBM412738 |
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n/a |
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Name | BDBM412738 |
Synonyms: | 2-(pyrrolidin-1-yl)-N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyridin-2-yl)acetamide | US10399987, Example 4 |
Type | Small organic molecule |
Emp. Form. | C23H21F3N8O |
Mol. Mass. | 482.461 |
SMILES | FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCCC3)c2)c2cc[nH]c2n1 |
Structure |
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