| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-1 [4-503,T204D] |
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| Ligand | BDBM412739 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assays |
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| IC50 | 0.530±n/a nM |
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| Citation |  Harikrishnan, LS; Fink, BE; Borzilleri, RM; Tonukunuru, G; Sankara Warrier, J TGF beta receptor antagonists US Patent US10399987 Publication Date 9/3/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| TGF-beta receptor type-1 [4-503,T204D] |
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| Name: | TGF-beta receptor type-1 [4-503,T204D] |
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| Synonyms: | ALK5 | SKR4 | TGF-beta receptor type-1 T204D | TGFBR1 | TGFR-1 T204D | TGFR1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 55650.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36897 T204D |
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| Residue: | 500 |
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| Sequence: | AVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTD
KVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGP
VELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYD
MTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWF
REAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMI
KLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATD
TIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHED
YQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARL
TALRIKKTLSQLSQQEGIKM
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| BDBM412739 |
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| n/a |
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| Name | BDBM412739 |
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| Synonyms: | 2-(4-methylpiperazin-1-yl)-N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyridin-2-yl)acetamide | US10399987, Example 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24F3N9O |
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| Mol. Mass. | 511.5023 |
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| SMILES | CN1CCN(CC(=O)Nc2cc(Nc3nc(nc4[nH]ccc34)-c3cccc(n3)C(F)(F)F)ccn2)CC1 |
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| Structure | 
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