| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-1 [4-503,T204D] |
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| Ligand | BDBM412742 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assays |
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| IC50 | 3.70±n/a nM |
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| Citation |  Harikrishnan, LS; Fink, BE; Borzilleri, RM; Tonukunuru, G; Sankara Warrier, J TGF beta receptor antagonists US Patent US10399987 Publication Date 9/3/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| TGF-beta receptor type-1 [4-503,T204D] |
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| Name: | TGF-beta receptor type-1 [4-503,T204D] |
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| Synonyms: | ALK5 | SKR4 | TGF-beta receptor type-1 T204D | TGFBR1 | TGFR-1 T204D | TGFR1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 55650.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36897 T204D |
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| Residue: | 500 |
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| Sequence: | AVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTD
KVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGP
VELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYD
MTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWF
REAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMI
KLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATD
TIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHED
YQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARL
TALRIKKTLSQLSQQEGIKM
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| BDBM412742 |
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| n/a |
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| Name | BDBM412742 |
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| Synonyms: | 2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyridin-4-yl)-5-((4-methylpiperazin-1-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | US10399987, Example 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23F3N8 |
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| Mol. Mass. | 468.4775 |
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| SMILES | CN1CCN(Cc2c[nH]c3nc(nc(Nc4ccncc4F)c23)-c2cccc(n2)C(F)F)CC1 |
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| Structure | 
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