| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-2 |
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| Ligand | BDBM412756 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assays |
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| IC50 | 50.0±n/a nM |
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| Citation |  Harikrishnan, LS; Fink, BE; Borzilleri, RM; Tonukunuru, G; Sankara Warrier, J TGF beta receptor antagonists US Patent US10399987 Publication Date 9/3/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| TGF-beta receptor type-2 |
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| Name: | TGF-beta receptor type-2 |
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| Synonyms: | TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64559.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586859 |
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| Residue: | 567 |
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| Sequence: | MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
LEHLDRLSGRSCSEEKIPEDGSLNTTK
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| BDBM412756 |
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| n/a |
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| Name | BDBM412756 |
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| Synonyms: | N-(4-((2-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyridin-2-yl)acetamide | US10399987, Example 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15N7O |
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| Mol. Mass. | 345.358 |
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| SMILES | CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccccn2)ccn1 |
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| Structure | 
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